Entrepreneurs are agents of innovation and creators of profit. The level of entrepreneurship is affected not only by individual activities but also by the macroeconomic and social environment and by national strategies. The ‘Belt and Road Initiative’ launched by the Chinese government provides many opportunities for Hong Kong’s economic and trade development. Entrepreneurial activity in Hong Kong has increased significantly in recent years, and the government of the HKSAR has implemented measures specifically to support youth entrepreneurship. Given this context, what impact will the Belt and Road Initiative have on entrepreneurship? What opportunities might it bring to the development of emerging enterprises? This paper provides an overview of the entrepreneurial activity in Hong Kong – based on Global Entrepreneurship Monitor data on the Belt and Road Initiative relevant countries – and discusses the opportunities that the Belt and Road Initiative brings for such activity and the potential benefits of the initiative entrepreneurship in Hong Kong.